pI: 5.0815 |
Length (AA): 239 |
MW (Da): 27133 |
Paralog Number:
5
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 233 | 2npm (A) | 21 | 259 | 42.00 | 0 | 1 | 1.5117 | -0.84 |
4 | 237 | 5nwj (A) | 4 | 243 | 37.00 | 0 | 1 | 1.50398 | -1.02 |
7 | 234 | 5yqg (B) | 3 | 236 | 38.00 | 0 | 1 | 1.47587 | -1.09 |
15 | 231 | 6fel (B) | 11 | 233 | 43.00 | 0 | 1 | 1.39475 | -0.64 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126706)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G10450 | 14-3-3-like protein GF14 lambda |
Arabidopsis thaliana | AT1G35160 | 14-3-3-like protein GF14 phi |
Arabidopsis thaliana | AT5G38480 | 14-3-3-like protein GF14 psi |
Arabidopsis thaliana | AT1G26480 | 14-3-3-like protein GF14 iota |
Arabidopsis thaliana | AT1G22300 | 14-3-3-like protein GF14 epsilon |
Arabidopsis thaliana | AT5G16050 | 14-3-3-like protein GF14 upsilon |
Arabidopsis thaliana | AT5G65430 | 14-3-3-like protein GF14 kappa |
Arabidopsis thaliana | AT4G09000 | 14-3-3-like protein GF14 chi |
Arabidopsis thaliana | AT1G34760 | 14-3-3-like protein GF14 omicron |
Arabidopsis thaliana | AT1G78300 | 14-3-3-like protein GF14 omega |
Arabidopsis thaliana | AT3G02520 | 14-3-3-like protein GF14 nu |
Babesia bovis | BBOV_II006430 | 14-3-3 protein |
Brugia malayi | Bm1_10970 | 14-3-3-like protein 2 |
Brugia malayi | Bm1_18190 | 14-3-3-like protein 2 |
Candida albicans | CaO19.3014 | likely 14-3-3 family protein, similar to S. cerevisiae BMH1 (YER177W) and BMH2 (YDR099W) which is involved in RAS protein signal |
Candida albicans | CaO19.10532 | likely 14-3-3 family protein, similar to S. cerevisiae BMH1 (YER177W) and BMH2 (YDR099W) which is involved in RAS protein signal |
Caenorhabditis elegans | CELE_F52D10.3 | Protein FTT-2, isoform B |
Cryptosporidium hominis | Chro.30161 | 14-3-3-like protein B (14-3-3B) |
Cryptosporidium parvum | cgd3_1290 | 14-3-3 domain containing protein |
Dictyostelium discoideum | DDB_G0269138 | hypothetical protein |
Drosophila melanogaster | Dmel_CG31196 | CG31196 gene product from transcript CG31196-RD |
Drosophila melanogaster | Dmel_CG17870 | CG17870 gene product from transcript CG17870-RE |
Echinococcus granulosus | EgrG_001192500 | 14-3-3 protein |
Echinococcus granulosus | EgrG_001060100 | 14-3-3 protein zeta:delta |
Echinococcus granulosus | EgrG_000364000 | 14-3-3 protein beta:alpha |
Echinococcus granulosus | EgrG_000231300 | 14-3-3 protein epsilon |
Echinococcus granulosus | EgrG_000314100 | 14-3-3 protein gamma |
Echinococcus granulosus | EgrG_000789700 | 14-3-3 protein |
Entamoeba histolytica | EHI_098280 | 14-3-3 protein 2 |
Entamoeba histolytica | EHI_006810 | 14-3-3 protein 3 |
Entamoeba histolytica | EHI_025360 | 14-3-3 protein 1 |
Echinococcus multilocularis | EmuJ_000231300 | 14-3-3 protein epsilon |
Echinococcus multilocularis | EmuJ_000314100 | |
Echinococcus multilocularis | EmuJ_001192500 | 14-3-3 protein |
Echinococcus multilocularis | EmuJ_001060100 | 14-3-3 protein zeta:delta |
Echinococcus multilocularis | EmuJ_000364000 | 14-3-3 protein beta:alpha |
Echinococcus multilocularis | EmuJ_000789700 | 14-3-3 protein |
Giardia lamblia | GL50803_6430 | 14-3-3 protein |
Homo sapiens | ENSG00000164924 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta |
Homo sapiens | ENSG00000166913 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta |
Homo sapiens | ENSG00000108953 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon |
Leishmania braziliensis | LbrM.35.3430 | 14-3-3 protein-like protein |
Leishmania braziliensis | LbrM.11.0040 | 14-3-3 protein, putative |
Leishmania donovani | LdBPK_110350.1 | 14-3-3 protein 2, putative |
Leishmania donovani | LdBPK_363360.1 | 14-3-3 protein 1, putative |
Leishmania infantum | LinJ.11.0350 | 14-3-3 protein, putative |
Leishmania infantum | LinJ.36.3360 | 14-3-3 protein-like protein |
Leishmania major | LmjF.36.3210 | 14-3-3 protein-like protein |
Leishmania major | LmjF.11.0350 | 14-3-3 protein, putative |
Leishmania mexicana | LmxM.11.0350 | 14-3-3 protein, putative |
Leishmania mexicana | LmxM.36.3210 | 14-3-3 protein-like protein |
Loa Loa (eye worm) | LOAG_05701 | hypothetical protein |
Mus musculus | ENSMUSG00000018326 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide |
Mus musculus | ENSMUSG00000020849 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide |
Mus musculus | ENSMUSG00000022285 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide |
Mus musculus | 102641764 | 14-3-3 protein zeta/delta-like |
Neospora caninum | NCLIV_024820 | 14-3-3 protein homolog |
Oryza sativa | 4345634 | Os08g0430500 |
Oryza sativa | 4329775 | Os02g0580300 |
Oryza sativa | 4333880 | Os03g0710800 |
Oryza sativa | 9269633 | Os11g0609600 |
Oryza sativa | 4336066 | Os04g0462500 |
Oryza sativa | 4350697 | Os11g0546900 |
Plasmodium berghei | PBANKA_0712600 | 14-3-3 protein |
Plasmodium falciparum | PF3D7_0818200 | 14-3-3 protein |
Plasmodium knowlesi | PKNH_0501800 | 14-3-3 protein, putative |
Plasmodium yoelii | PY05990 | 14-3-3 protein |
Plasmodium yoelii | PY01841 | 14-3-3 protein |
Saccharomyces cerevisiae | YER177W | 14-3-3 family protein BMH1 |
Saccharomyces cerevisiae | YDR099W | 14-3-3 family protein BMH2 |
Schistosoma japonicum | Sjp_0092590 | ko:K06630 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation, putative |
Schistosoma japonicum | Sjp_0204420 | ko:K06630 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation, putative |
Schistosoma mansoni | Smp_034840.2 | hypothetical protein |
Schistosoma mansoni | Smp_034840.1 | hypothetical protein |
Schistosoma mansoni | Smp_034840.3 | hypothetical protein |
Schistosoma mansoni | Smp_002410 | hypothetical protein |
Schmidtea mediterranea | mk4.000081.04 | 14-3-3 protein epsilon |
Schmidtea mediterranea | mk4.002915.00 | 14-3-3 protein epsilon |
Schmidtea mediterranea | mk4.016050.00 | 14-3-3 protein zeta |
Schmidtea mediterranea | mk4.001714.01 | 14-3-3 protein zeta |
Schmidtea mediterranea | mk4.005215.00 | |
Schmidtea mediterranea | mk4.009079.02 | 14-3-3 protein zeta |
Schmidtea mediterranea | mk4.007483.00 | |
Schmidtea mediterranea | mk4.000094.06 | |
Schmidtea mediterranea | mk4.007444.00 | 14-3-3 protein zeta |
Schmidtea mediterranea | mk4.001319.01 | 14-3-3 protein zeta |
Trypanosoma brucei gambiense | Tbg972.11.10700 | 14-3-3 protein-like protein, putative |
Trypanosoma brucei gambiense | Tbg972.11.7800 | 14-3-3 protein-like protein, putative |
Trypanosoma brucei | Tb927.11.6870 | 14-3-3 protein 2 |
Trypanosoma brucei | Tb927.11.9530 | 14-3-3 protein 1 |
Trypanosoma congolense | TcIL3000.11.10000 | 14-3-3 protein 1, putative |
Trypanosoma congolense | TcIL3000.11.7440 | 14-3-3 protein 2, putative |
Trypanosoma cruzi | TcCLB.506775.80 | 14-3-3 protein 2, putative |
Trypanosoma cruzi | TcCLB.511589.130 | 14-3-3 protein 1, putative |
Trypanosoma cruzi | TcCLB.511167.90 | 14-3-3 protein 2, putative |
Trypanosoma cruzi | TcCLB.508851.180 | 14-3-3 protein 1, putative |
Toxoplasma gondii | TGME49_263090 | 14-3-3 protein |
Theileria parva | TP02_0607 | 14-3-3 protein, putative |
Trichomonas vaginalis | TVAG_462940 | 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative |
Trichomonas vaginalis | TVAG_454380 | 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative |
Trichomonas vaginalis | TVAG_251260 | 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative |
Trichomonas vaginalis | TVAG_469400 | 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative |
Trichomonas vaginalis | TVAG_198430 | 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.1290 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.1290 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.1290 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.1290 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb11.02.4700 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.4700 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.4700 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.4700 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F52D10.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F52D10.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F52D10.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F52D10.3 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_0712600 | Plasmodium berghei | Essential | plasmo |
TGME49_263090 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | Compounds | References |